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Circulating donor-specific cytotoxic T lymphocytes with high avidity for donor human leukocyte antigens in pediatric and adult cardiac allograft valved conduit recipients.

Authors
  • Oei, F B
  • Welters, M J
  • Knoop, C J
  • Vaessen, L M
  • Stegmann, A P
  • Weimar, W
  • Bogers, A J
Type
Published Article
Journal
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery
Publication Date
Oct 01, 2000
Volume
18
Issue
4
Pages
466–472
Identifiers
PMID: 11024386
Source
Medline
License
Unknown

Abstract

Implantation of cryopreserved human AVC induces an increase in the total number of circulating CTLp directed against donor HLA class I in both adults and children. The shift towards more destructive high-avidity CTLp in the peripheral blood indicates their potential damaging effect towards the heart valve allograft.

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