Affordable Access

[Circulating cell-free DNA as biomarker for cancer *header*].

Authors
  • Isomursu, Aleksi
  • Kononen, Juha
  • Kuopio, Teijo
Type
Published Article
Journal
Duodecim; laaketieteellinen aikakauskirja
Publication Date
Jan 01, 2015
Volume
131
Issue
5
Pages
424–432
Identifiers
PMID: 26237904
Source
Medline
License
Unknown

Abstract

The rapid accumulation of mutations in cancers and the resulting clonal heterogeneity frequently lead to generation of drug-resistant populations of cancer cells. Examinations requiring a tissue biopsy are invasive, making real-time monitoring of the disease difficult. One alternative to support tissue-based testing is fluid biopsy. Malignant cells release to the patient's circulation DNA, which contains somatic mutations and epigenetic changes characteristic of each cancer. Sufficiently sensitive methods of investigation enable the detection of tumor DNA in the blood sample, whereby it can be utilized e.g. in the monitoring of disease progression.

Report this publication

Statistics

Seen <100 times