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Circulating blood endothelial nitric oxide synthase contributes to the regulation of systemic blood pressure and nitrite homeostasis.

Authors
  • Wood, Katherine C
  • Cortese-Krott, Miriam M
  • Kovacic, Jason C
  • Noguchi, Audrey
  • Liu, Virginia B
  • Wang, Xunde
  • Raghavachari, Nalini
  • Boehm, Manfred
  • Kato, Gregory J
  • Kelm, Malte
  • Gladwin, Mark T
Type
Published Article
Journal
Arteriosclerosis Thrombosis and Vascular Biology
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Aug 01, 2013
Volume
33
Issue
8
Pages
1861–1871
Identifiers
DOI: 10.1161/ATVBAHA.112.301068
PMID: 23702660
Source
Medline
Keywords
License
Unknown

Abstract

These are the first studies to definitively establish a role for a blood-borne eNOS, using cross-transplant chimera models, that contributes to the regulation of blood pressure and nitrite homeostasis. This work provides evidence suggesting that erythrocyte eNOS may mediate this effect.

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