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Circular RNAs in renal cell carcinoma: implications for tumorigenesis, diagnosis, and therapy

Authors
  • Wang, Ying1
  • Zhang, Yunjing1
  • Wang, Ping2
  • Fu, Xianghui3
  • Lin, Weiqiang1
  • 1 Institute of Translational Medicine, Zhejiang University School of Medicine, Jinhua, Zhejiang, 322000, China , Jinhua (China)
  • 2 the First Affiliated Hospital, Zhejiang University School of Medicine, Hangzhou, Zhejiang, 310003, China , Hangzhou (China)
  • 3 West China Hospital, Sichuan University and Collaborative Innovation Center of Biotherapy, Chengdu, Sichuan, 610041, China , Chengdu (China)
Type
Published Article
Journal
Molecular Cancer
Publisher
Springer (Biomed Central Ltd.)
Publication Date
Oct 14, 2020
Volume
19
Issue
1
Identifiers
DOI: 10.1186/s12943-020-01266-7
Source
Springer Nature
Keywords
License
Green

Abstract

Renal cell carcinoma (RCC) is the most common malignant kidney tumor and has a high incidence rate. Circular RNAs (circRNAs) are noncoding RNAs with widespread distribution and diverse cellular functions. They are highly stable and have organ- and tissue-specific expression patterns. CircRNAs have essential functions as microRNA sponges, RNA-binding protein- and transcriptional regulators, and protein translation templates. Recent reports have shown that circRNAs are abnormally expressed in RCC and act as important regulators of RCC carcinogenesis and progression. Moreover, circRNAs have emerged as potential biomarkers for RCC diagnosis and prognosis and targets for developing new treatments. However, further studies are needed to better understand the functions of circRNAs in RCC. In this review, we summarize and discuss the recent research progress on RCC-associated circRNAs, with a focus on their potential for RCC diagnosis and targeted therapy.

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