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Circular RNAS: novel biomarkers of disease activity in systemic lupus erythematosus?

Authors
  • Cortes, Raquel1, 2
  • Forner, Maria J3, 4
  • 1 Cardiometabolic and Renal Risk Research Group, INCLIVA Biomedical Research Institute, Avd. Menéndez Pelayo, acceso 4, Valencia 46010, Spain. , (Spain)
  • 2 Genomic and Genetic Diagnosis Unit, INCLIVA Biomedical Research Institute, Avd. Menéndez Pelayo, acceso 4, Valencia 46010, Spain. , (Spain)
  • 3 Cardiometabolic and Renal Risk Research Group, INCLIVA Biomedical Research Institute, Avd. Menéndez Pelayo, acceso 4, Valencia 46010, Spain [email protected] , (Spain)
  • 4 Internal Medicine, Clinic Universitary Hospital, Avd. Blasco Ibañez, 17, Valencia 46010, Spain. , (Spain)
Type
Published Article
Journal
Clinical Science
Publisher
Portland Press
Publication Date
May 15, 2019
Volume
133
Issue
9
Pages
1049–1052
Identifiers
DOI: 10.1042/CS20180826
PMID: 31064795
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Circular RNAs (circRNAs) are a class of non-coding RNAs that regulate gene expression by acting as competitive endogenous RNAs (ceRNAs) and modulating gene transcription. Several studies support the implication of circRNAs in a variety of human diseases, but research on the role of circRNAs in systemic lupus erythematosus (SLE) is lacking. In a study recently published in Clinical Science (2018), Zhang et al. identified hsa_circ_0012919 as a potential biomarker of disease activity in SLE patients. The authors observed different circRNA expression between SLE patients and healthy controls, an association with clinical variables and with the abnormal DNA methylation present in SLE CD4+ T cells. Finally, Zhang et al. demonstrated that hsa_circ_0012919 acts as a miRNA sponge for miR-125a-3p, regulating the gene expression of targets RANTES and KLF13 that are involved in the physiology and pathophysiology of acute and chronic inflammatory processes. These findings support the role of circRNAs in the pathophysiology of SLE. © 2019 The Author(s). Published by Portland Press Limited on behalf of the Biochemical Society.

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