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Circular RNA circ-FoxO3 Inhibits Myoblast Cells Differentiation

Authors
  • xiaoyue, li
  • cunyuan, li
  • liu, zhijin
  • wei, ni
  • yao, rui
  • yueren, xu
  • quan, renzhe
  • zhang, mengdan
  • huixiang, li
  • liu, li
  • shengwei, hu
Publication Date
Jun 19, 2019
Source
MDPI
Keywords
Language
English
License
Green
External links

Abstract

0.05) after inhibiting the expression of circ-FoxO3 in myoblast cells. Combining the results of bioinformatics analysis and the dual luciferase reporter experiment, we found that circ-FoxO3 is a sponge of miR-138-5p, which regulates muscle differentiation. Our study shows that circ-FoxO3 can inhibit the differentiation of C2C12 myoblast cells and lay a scientific foundation for further study of skeletal muscle development at circRNA levels.

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