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Circuits for integrating learned and innate valences in the insect brain.

Authors
  • Eschbach, Claire1
  • Fushiki, Akira2
  • Winding, Michael1
  • Afonso, Bruno3
  • Andrade, Ingrid V3
  • Cocanougher, Benjamin T3
  • Eichler, Katharina4
  • Gepner, Ruben5
  • Si, Guangwei6
  • Valdes-Aleman, Javier7
  • Fetter, Richard D3
  • Gershow, Marc8
  • Jefferis, Gregory Sxe9
  • Samuel, Aravinthan Dt10
  • Truman, James W3
  • Cardona, Albert11
  • Zlatic, Marta12
  • 1 Zoology, University of Cambridge, Cambridge, United Kingdom. , (United Kingdom)
  • 2 Neuroscience, Columbia University, Zuckerman Institute, New York, United States. , (United States)
  • 3 Janelia Research Campus, Howard Hughes Medical Institute, Ashburn, United States. , (United States)
  • 4 Institute of Neurobiology, University of Puerto Rico Medical Sciences Campus, San Juan, Puerto Rico. , (Puerto Rico)
  • 5 Department of Physics, New York University, New York, United States. , (United States)
  • 6 Department of Physics and Center for Brain Science, Harvard University, Cambridge, United States. , (United States)
  • 7 Molecular Cell and Developmental Biology, University of California, Los Angeles, United States. , (United States)
  • 8 Department of Physics, Center for Neural Science, Neuroscience Institute, New York University, New York, United States. , (United States)
  • 9 Neurobiology Division, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom. , (United Kingdom)
  • 10 Physics, Harvard University, Cambridge, United States. , (United States)
  • 11 Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, United Kingdom. , (United Kingdom)
  • 12 Neurobiology, MRC Laboratory of Molecular Biology, Cambridge, United Kingdom. , (United Kingdom)
Type
Published Article
Journal
eLife
Publisher
"eLife Sciences Organisation, Ltd."
Publication Date
Nov 10, 2021
Volume
10
Identifiers
DOI: 10.7554/eLife.62567
PMID: 34755599
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Animal behavior is shaped both by evolution and by individual experience. Parallel brain pathways encode innate and learned valences of cues, but the way in which they are integrated during action-selection is not well understood. We used electron microscopy to comprehensively map with synaptic resolution all neurons downstream of all Mushroom Body output neurons (encoding learned valences) and characterized their patterns of interaction with Lateral Horn neurons (encoding innate valences) in Drosophila larva. The connectome revealed multiple convergence neuron types that receive convergent Mushroom Body and Lateral Horn inputs. A subset of these receives excitatory input from positive-valence MB and LH pathways and inhibitory input from negative-valence MB pathways. We confirmed functional connectivity from LH and MB pathways and behavioral roles of two of these neurons. These neurons encode integrated odor value and bidirectionally regulate turning. Based on this we speculate that learning could potentially skew the balance of excitation and inhibition onto these neurons and thereby modulate turning. Together, our study provides insights into the circuits that integrate learned and innate to modify behavior. © 2021, Eschbach et al.

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