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Circadian clocks and vascular function.

Authors
  • Paschos, Georgios K
  • FitzGerald, Garret A
Type
Published Article
Journal
Circulation Research
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Mar 19, 2010
Volume
106
Issue
5
Pages
833–841
Identifiers
DOI: 10.1161/CIRCRESAHA.109.211706
PMID: 20299673
Source
Medline
License
Unknown

Abstract

The circadian clock regulates many aspects of physiology, including cardiovascular function. Internal oscillators exist in endothelial, smooth muscle cells, and fibroblasts of the vasculature. Vascular tone and thrombus formation, 2 key elements of vascular function with regard to adverse cardiovascular events, exhibit diurnal rhythmicity. In this review, we describe changes in vascular function that result from genetic disruption of discrete elements of the circadian clock.

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