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Circadian clock: linking epigenetics to aging.

Authors
  • Orozco-Solis, Ricardo1
  • Sassone-Corsi, Paolo2
  • 1 Center for Epigenetics and Metabolism, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, United States. , (United States)
  • 2 Center for Epigenetics and Metabolism, Department of Biological Chemistry, University of California, Irvine, Irvine, CA 92697, United States. Electronic address: [email protected] , (United States)
Type
Published Article
Journal
Current opinion in genetics & development
Publication Date
June 2014
Volume
26
Pages
66–72
Identifiers
DOI: 10.1016/j.gde.2014.06.003
PMID: 25033025
Source
Medline
License
Unknown

Abstract

Circadian rhythms are generated by an intrinsic cellular mechanism that controls a large array of physiological and metabolic processes. There is erosion in the robustness of circadian rhythms during aging, and disruption of the clock by genetic ablation of specific genes is associated with aging-related features. Importantly, environmental conditions are thought to modulate the aging process. For example, caloric restriction is a very strong environmental effector capable of delaying aging. Intracellular pathways implicating nutrient sensors, such as SIRTs and mTOR complexes, impinge on cellular and epigenetic mechanisms that control the aging process. Strikingly, accumulating evidences indicate that these pathways are involved in both the modulation of the aging process and the control of the clock. Hence, innovative therapeutic strategies focused at controlling the circadian clock and the nutrient sensing pathways might beneficially influence the negative effects of aging.

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