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The CINs of the centromere.

Authors
  • Forsburg, Susan L
Type
Published Article
Journal
Biochemical Society Transactions
Publisher
Portland Press
Publication Date
Dec 01, 2013
Volume
41
Issue
6
Pages
1706–1711
Identifiers
DOI: 10.1042/BST20130146
PMID: 24256279
Source
Medline
License
Unknown

Abstract

Replication stress is a significant contributor to genome instability. Recent studies suggest that the centromere is particularly susceptible to replication stress and prone to rearrangements and genome damage, as well as chromosome loss. This effect is enhanced by loss of heterochromatin. The resulting changes in genetic organization, including chromosome loss, increased mutation and loss of heterozygosity, are important contributors to malignant growth.

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