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cIMPACT-NOW update 6: new entity and diagnostic principle recommendations of the cIMPACT-Utrecht meeting on future CNS tumor classification and grading.

  • Louis, David N1
  • Wesseling, Pieter2, 3
  • Aldape, Kenneth4
  • Brat, Daniel J5
  • Capper, David6, 7
  • Cree, Ian A8
  • Eberhart, Charles9
  • Figarella-Branger, Dominique10
  • Fouladi, Maryam11
  • Fuller, Gregory N12
  • Giannini, Caterina13, 14
  • Haberler, Christine15
  • Hawkins, Cynthia16
  • Komori, Takashi17
  • Kros, Johan M18
  • Ng, H K19
  • Orr, Brent A20
  • Park, Sung-Hye21
  • Paulus, Werner22
  • Perry, Arie23
  • And 13 more
  • 1 Department of Pathology, Massachusetts General Hospital, Harvard Medical School, Boston, MA.
  • 2 Department of Pathology, Amsterdam University Medical Centers/VUmc, Amsterdam, The Netherlands. , (Netherlands)
  • 3 Princess Máxima Center for Pediatric Oncology, Utrecht, The Netherlands. , (Netherlands)
  • 4 Laboratory of Pathology, National Cancer Institute, Bethesda, MD.
  • 5 Department of Pathology, Northwestern University Feinberg School of Medicine, Chicago, IL.
  • 6 Department of Neuropathology, Humboldt-Universität zu Berlin and Berlin Institute of Health, Corporate Member of Freie Universität Berlin, Charité - Universitätsmedizin Berlin, Berlin, Germany. , (Germany)
  • 7 German Cancer Research Center, German Cancer Consortium, Partner Site Berlin, Heidelberg, Germany. , (Germany)
  • 8 International Agency for Research on Cancer, World Health Organization, Lyon, France. , (France)
  • 9 Department of Pathology, Johns Hopkins School of Medicine, Baltimore, MD.
  • 10 Service d'Anatomie Pathologique et de Neuropathologie, Hôpital de la Timone, Institut de Neurophysiopathology, Aix-Marseille Univ, APHM, CNRS, Marseille, France. , (France)
  • 11 Department of Pediatrics, Cincinnati Children's Hospital Medical Center, University of Cincinnati, Cincinnati, OH.
  • 12 Department of Pathology, University of Texas MD Anderson Cancer Center, Houston, TX.
  • 13 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, MN.
  • 14 Department of Biomedical and Neuromotor Sciences, Alma Mater Studiorum, University of Bologna, Bologna, Italy. , (Italy)
  • 15 Institute of Neurology, Medical University of Vienna, Vienna, Austria. , (Austria)
  • 16 Department of Paediatric Laboratory Medicine, The Hospital for Sick Children, University of Toronto, Toronto, Canada. , (Canada)
  • 17 Department of Laboratory Medicine and Pathology, Tokyo Metropolitan Neurological Hospital, Tokyo, Japan. , (Japan)
  • 18 Department of Pathology, Erasmus Medical Center, Rotterdam, The Netherlands. , (Netherlands)
  • 19 Department of Anatomical and Cellular Pathology, Chinese University of Hong Kong, Hong Kong, China. , (China)
  • 20 Department of Pathology, St. Jude Children's Research Hospital, Memphis, TN.
  • 21 Department of Pathology, Seoul National University College of Medicine, Seoul, South Korea. , (North Korea)
  • 22 Institute of Neuropathology, University Hospital Munster, Munster, Germany. , (Germany)
  • 23 Department of Pathology, University of California San Francisco, San Francisco, CA.
  • 24 Department of Neuropathology, DGNN Brain Tumor Reference Center, University of Bonn, Bonn, Germany. , (Germany)
  • 25 Department of Neuropathology, Heinrich Heine University, Duesseldorf, Germany. , (Germany)
  • 26 German Cancer Consortium, Partner Site Essen/Duesseldorf, Essen, Germany. , (Germany)
  • 27 Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, NY.
  • 28 Department of Pathology, Cambridge University Hospitals NHS Foundation Trust, Cambridge, UK.
  • 29 Department of Neuropathology, Institute of Pathology, Ruprecht-Karls-University, Heidelberg, Germany. , (Germany)
  • 30 Clinical Cooperation Unit Neuropathology, German Cancer Research Center, German Cancer Consortium, Heidelberg, Germany. , (Germany)
  • 31 Hopp Children's Cancer Center, NCT Heidelberg, Heidelberg, Germany. , (Germany)
  • 32 Department of Pathology, All India Institute of Medical Sciences, New Delhi, India. , (India)
  • 33 Department of Pediatrics, The Hospital for Sick Children, University of Toronto, Toronto, Canada. , (Canada)
  • 34 Department of Neurology, Erasmus MC Cancer Institute, Rotterdam, The Netherlands. , (Netherlands)
  • 35 Department of Neurology, University Hospital and University of Zurich, Zurich, Switzerland. , (Switzerland)
Published Article
Brain Pathology
Wiley (Blackwell Publishing)
Publication Date
Apr 19, 2020
DOI: 10.1111/bpa.12832
PMID: 32307792


cIMPACT-NOW (the Consortium to Inform Molecular and Practical Approaches to CNS Tumor Taxonomy) was established to evaluate and make practical recommendations on recent advances in the field of CNS tumor classification, particularly in light of the rapid progress in molecular insights into these neoplasms. For Round 2 of its deliberations, cIMPACT-NOW Working Committee 3 was reconstituted and convened in Utrecht, The Netherlands, for a meeting designed to review putative new CNS tumor types in advance of any future World Health Organization meeting on CNS tumor classification. In preparatory activities for the meeting and at the actual meeting, a list of possible entities was assembled and each type and subtype debated. Working Committee 3 recommended that a substantial number of newly recognized types and subtypes should be considered for inclusion in future CNS tumor classifications. In addition, the group endorsed a number of principles-relating to classification categories, approaches to classification, nomenclature, and grading-that the group hopes will also inform the future classification of CNS neoplasms. © 2020 International Society of Neuropathology.

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