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Ciliary neurotrophic factor improves nerve conduction and ameliorates regeneration deficits in diabetic rats.

Authors
  • Mizisin, Andrew P
  • Vu, Yvonne
  • Shuff, Michelle
  • Calcutt, Nigel A
Type
Published Article
Journal
Diabetes
Publisher
American Diabetes Association
Publication Date
Jul 01, 2004
Volume
53
Issue
7
Pages
1807–1812
Identifiers
PMID: 15220205
Source
Medline
License
Unknown

Abstract

Ciliary neurotrophic factor (CNTF) protein and bioactivity are reduced in the peripheral nerve of hyperglycemic rats with a cause related to metabolism of hexose sugars by aldose reductase. Here the efficacy of CNTF treatment against disorders of nerve function in hyperglycemic rats was investigated. CNTF treatment from the onset of 8 weeks of galactose feeding prevented nerve conduction slowing in a dose-dependent manner. Streptozotocin-induced diabetic rats were maintained for 4 weeks before CNTF treatment was initiated. Four weeks of CNTF treatment significantly improved nerve conduction compared with untreated diabetic rats and also normalized the recovery of toe spread after sciatic nerve crush. One week of CNTF treatment significantly improved the distance of sensory nerve regeneration achieved after nerve crush injury compared with untreated diabetic rats. CNTF was without effects on any parameter in nondiabetic rats. Eight weeks of diabetes did not impair macrophage recruitment 1 and 7 days after nerve crush; neither did intraneural injections of CNTF and CNTFRalpha enhance recruitment in diabetic or control rats. These observations point to the potential utility of CNTF in treating nerve dysfunction in experimental diabetes.

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