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Ciliary alterations in hamster respiratory tract epithelium after exposure to carcinogens and cigarette smoke.

Authors
  • Reznik-Schüller, H
Type
Published Article
Journal
Cancer Letters
Publisher
Elsevier
Publication Date
Sep 01, 1975
Volume
1
Issue
1
Pages
7–13
Identifiers
PMID: 1235059
Source
Medline
License
Unknown

Abstract

Alterations in the ultrastructure of cilia were found to be one of the initial stages in the development of benzo(a)pyrene induced cancers in the trachea and bronchi of Syrian golden hamsters, as well as in the bronchi from which pulmonary adenocarcinomata originated after European hamsters were treated with N-dibutylnitrosamine. Similar abnormalities of cilia occurred in the respiratory epithelia of Syrian golden hamsters after one year of daily exposure to cigarette smoke.

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