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Cigarette smoking accelerates the development of diminished ovarian reserve as evidenced by the clomiphene citrate challenge test.

Authors
  • Sharara, F I
  • Beatse, S N
  • Leonardi, M R
  • Navot, D
  • Scott, R T Jr
Type
Published Article
Journal
Fertility and Sterility
Publisher
Elsevier
Publication Date
Aug 01, 1994
Volume
62
Issue
2
Pages
257–262
Identifiers
PMID: 8034069
Source
Medline
License
Unknown

Abstract

Women who smoke have an accelerated development of clinically detectable diminished ovarian reserve. Additionally, the fact that women who smoke cigarettes with normal ovarian reserve have ovarian responses and PRs that are equivalent to age-matched nonsmoking controls suggests that diminished ovarian reserve may be a principal mechanism reducing fecundity among women who smoke cigarettes.

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