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Cigarette smoke components are not very effective in directly inactivating alpha 1-proteinase inhibitor.

Authors
  • Wyss, A
  • Virca, G D
  • Schnebli, H P
Type
Published Article
Journal
Hoppe-Seyler's Zeitschrift fur physiologische Chemie
Publication Date
April 1984
Volume
365
Issue
4
Pages
511–516
Identifiers
PMID: 6329941
Source
Medline
License
Unknown

Abstract

Cigarette smoke was found to be rather ineffective in inactivating alpha 1-proteinase inhibitor (alpha 1-PI) in aqueous solution, whereas a slow inactivation of alpha 1-PI by a dimethyl sulfoxide extract of whole cigarette smoke condensate was observed. However, this inactivation could only partially be prevented by antioxidants indicating that it is not, or at least not exclusively, due to oxidation. The bulk of inactive alpha 1-PI found in lung lavage fluids from smokers is thus probably generated through endogenous mechanisms and not through smoke components directly.

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