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Chronopharmacokinetic and bioequivalence studies of two formulations of trimipramine after oral administration in man.

Authors
  • Bougerolle, A M
  • Chabard, J L
  • Jbilou, M
  • Dordain, G
  • Eschalier, A
  • Aumaitre, O
  • Gaillot, J
  • Piron, J J
  • Petit, J
  • Berger, J A
Type
Published Article
Journal
European journal of drug metabolism and pharmacokinetics
Publication Date
Jan 01, 1989
Volume
14
Issue
2
Pages
139–144
Identifiers
PMID: 2591418
Source
Medline
License
Unknown

Abstract

The bioavailability of two oral formulations of trimipramine, tablets and solution, was performed in twelve healthy volunteers, in a cross-over study. Each formulation was administered in the morning after a fasted period, and in the evening after a meal, in order to evaluate the role of both administration time and food consumption on the plasma kinetic parameters, under usual therapeutic conditions. A high interindividual variability of data was found. First, the extent of bioavailability was identical for the two formulations but the rate of bioavailability seemed to be different, with the p.o. solution, being more rapidly absorbed (tmax = 1.50 h). The effect of administration time was more obvious for the solution as shown by a lower quantitative absorption as well as a delay in time to reach the maximal concentration. Regardless of formulation and administration time, the t1/2 beta was about 10 hours and the mean MRT value was 11 hours.

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