The ‘Cuarto Real de Santo Domingo’ of Granada, declared a Site of Cultural Interest in 1919, holds one of the most important conserved buildings from the period of transition between Almohad and Nasrid art. Located in the Realejo quarter, in the area previously known as the Alfareros or old potter´s quarter, this royal complex has been subject to important and controversial interventions throughout its history. The present study aims to investigate its materiality by analysing the historical development of the archaeological information perceived in its space and form. The main construction achievements are marked on a timeline, and the features of the construction systems used are analysed to establish the spatial and temporal condition of the architecture and the place. Special value is given to the invariable features of its geometry and material condition as essential elements to define the architectural footprint of this unique heritage.