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Chronic thromboembolic pulmonary hypertension in Spain: a decade of change.

Authors
  • Martínez-Santos, Paula1
  • Velázquez-Martín, María Teresa2
  • Barberá, Joan Albert3
  • Fernández Pérez, Cristina4
  • López-Meseguer, Manuel5
  • López-Reyes, Raquel6
  • Martínez-Meñaca, Amaya7
  • Lara-Padrón, Antonio8
  • Domingo-Morera, Juan Antonio9
  • Blanco, Isabel10
  • Escribano-Subías, Pilar11
  • 1 Servicio de Cardiología, Hospital Universitario Puerta de Hierro Majadahonda, Majadahonda, Madrid, Spain. , (Spain)
  • 2 Unidad de Hipertensión Pulmonar, Servicio de Cardiología, Hospital Universitario 12 de Octubre, Madrid, Spain. , (Spain)
  • 3 Servicio de Neumología, Hospital Clínic, Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Universidad de Barcelona, Barcelona, Spain; Servicio de Neumología, Hospital Universitario Miguel Servet, Zaragoza, Spain. , (Spain)
  • 4 Servicio de Medicina Preventiva, Hospital Universitario San Carlos, Madrid, Spain. , (Spain)
  • 5 Servicio de Neumología, Hospital Universitario Vall d'Hebron, Barcelona, Spain; Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Madrid, Spain. , (Spain)
  • 6 Servicio de Neumología, Hospital Universitario La Fe, Valencia, Spain. , (Spain)
  • 7 Servicio de Neumología, Hospital Universitario Marqués de Valdecilla, Santander, Cantabria, Spain. , (Spain)
  • 8 Servicio de Cardiología, Hospital Universitario de Canarias, Sta. Cruz de Tenerife, Spain. , (Spain)
  • 9 Servicio de Neumología, Hospital Universitario Miguel Servet, Zaragoza, Spain. , (Spain)
  • 10 Servicio de Neumología, Hospital Clínic, Instituto de Investigaciones Biomédicas August Pi i Sunyer (IDIBAPS), Universidad de Barcelona, Barcelona, Spain; Centro de Investigación Biomédica en Red Enfermedades Respiratorias (CIBERES), Madrid, Spain. , (Spain)
  • 11 Unidad de Hipertensión Pulmonar, Servicio de Cardiología, Hospital Universitario 12 de Octubre, Madrid, Spain; Centro de Investigación Biomédica en Red Enfermedades Cardiovasculares (CIBERCV), Madrid, Spain. Electronic address: [email protected] , (Spain)
Type
Published Article
Journal
Revista espanola de cardiologia (English ed.)
Publication Date
May 01, 2021
Volume
74
Issue
5
Pages
384–392
Identifiers
DOI: 10.1016/j.rec.2020.06.006
PMID: 32654945
Source
Medline
Keywords
Language
Spanish
License
Unknown

Abstract

Chronic thromboembolic pulmonary hypertension (CTEPH) treatment has evolved in the last decade. However, there is scarce information on the long-term impact of this progress in a real-life population at a national level. This study was designed to analyze the characteristics of CTEPH patients in Spain over the last decade. We prospectively collected epidemiological, clinical, and prognostic data from CTEPH patients consecutively included in the Spanish REHAP registry from January 1, 2007, to December 31, 2018. We evaluated differences over time, establishing 2013 as the reference date for analysis. Propensity scores for interventional treatment were calculated using a multivariable logistic regression model. A total of 1019 patients were included; 659 (64.4%) were evaluated at a national CTEPH center. Overall, 350 patients (34.3%) were selected for surgery and 97 (9.6%) for percutaneous treatment. Patients diagnosed between 2007 and 2012 died more frequently than those diagnosed from 2013 onward (HR, 1.83; 95%CI, 1.07-3.15; P=.027). Within the subgroup of patients adjusted by propensity score, baseline pulmonary vascular resistance and the 6-minute walk test distance also determined the outcome (HR, 1.24; 95%CI, 1.15-1.33; P=.011; and HR, 0.93; 95%CI, 0.90-0.97; P=.001, respectively). High survival rates were found in patients who underwent an invasive procedure (pulmonary endarterectomy or balloon pulmonary angioplasty). CTEPH diagnosis and prognosis have consistently improved in the last decade. Baseline disease severity determines the risk profile. Patients who undergo pulmonary endarterectomy or balloon pulmonary angioplasty have better outcomes. Copyright © 2020 Sociedad Española de Cardiología. Published by Elsevier España, S.L.U. All rights reserved.

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