Affordable Access

deepdyve-link
Publisher Website

Chronic leukaemias in the community

Authors
  • Li, Eric Wenlong
  • Yeung, David
  • Fuller, Stephen
Type
Published Article
Journal
Australian Prescriber
Publisher
NPS MedicineWise
Publication Date
Aug 03, 2020
Volume
43
Issue
4
Pages
126–130
Identifiers
DOI: 10.18773/austprescr.2020.034
PMID: 32921888
PMCID: PMC7450777
Source
PubMed Central
Keywords
License
Unknown

Abstract

Patients with chronic myeloid leukaemia and chronic lymphocytic leukaemia are now predominantly managed in an outpatient setting, with infrequent need for hospital-based therapy. New targeted oral treatments have transformed survival outcomes. An increasing number of patients now have a life expectancy approaching that of the general population. Suboptimal drug adherence is common and a key reason for therapy failure and poor clinical outcomes. The pharmacokinetics of new oral targeted drugs are significantly impacted by drug–drug interactions and an altered gastric pH. Long-term use of some of the new oral drugs is associated with complications, including cardiovascular events and infections, which can be fatal if not recognised.

Report this publication

Statistics

Seen <100 times