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Chronic immune complex disease: behavioral and immunological correlates.

Authors
  • Hoffman, S A
  • Shucard, D W
  • Harbeck, R J
  • Hoffman, A A
Type
Published Article
Journal
Journal of neuropathology and experimental neurology
Publication Date
Jan 01, 1978
Volume
37
Issue
4
Pages
426–436
Identifiers
PMID: 150457
Source
Medline
License
Unknown

Abstract

Using a fear avoidance paradigm, behavioral effects were seen in Sprague-Dawley rats in which chronic immune complex disease was induced. These effects were related to changes in urine protein that developed during the course of the experiment. Experimental animals also had glomerular deposits of rat gamma globulin and BSA as determined by immunofluorescence; C3 deposits were observed in half of these animals. BSA and/or rat gamma-globulin, but not C3, was seen in the choroid plexus of half of the experimental animals. This is the first study to report behavioral changes associated with the induction of chronic immune complex disease in experimental animals.

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