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Chronic imipramine treatment partially reverses the long-term changes of hippocampal synaptic plasticity in socially stressed rats.

Authors
  • Von Frijtag, J C
  • Kamal, A
  • Reijmers, L G
  • Schrama, L H
  • van den Bos, R
  • Spruijt, B M
Type
Published Article
Journal
Neuroscience Letters
Publisher
Elsevier
Publication Date
Aug 31, 2001
Volume
309
Issue
3
Pages
153–156
Identifiers
PMID: 11514064
Source
Medline
License
Unknown

Abstract

In the present study, we investigated whether synaptic plasticity changes in the hippocampus of depressive-like socially stressed rats could be reversed by chronic antidepressant treatment. To that end, rats were either defeated and subsequently individually housed or subjected to control treatment followed by social housing. After a period of at least 3 months, rats were either treated chronically with imipramine (20 mg/kg per day, per os for at least 3 months) or the solvent solution (i.e. water). Then, long-term potentiation and depression were measured in the CA1 region of the hippocampus in vitro. Chronic imipramine treatment partially restored the attenuated induction of long-term potentiation and suppressed the facilitation of long-term depression-induction in socially stressed rats. The altered synaptic plasticity after social stress is discussed in relation to cognitive deficits and hippocampal changes that are observed in depressive patients.

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