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Chronic hepatitis B in Italy: new features of an old disease--approaching the universal prevalence of hepatitis B e antigen-negative cases and the eradication of hepatitis D infection.

Authors
  • Sagnelli, Evangelista
  • Stroffolini, Tommaso
  • Mele, Alfonso
  • Imparato, Michele
  • Almasio, Piero L
Type
Published Article
Journal
Clinical Infectious Diseases
Publisher
Oxford University Press
Publication Date
Jan 01, 2008
Volume
46
Issue
1
Pages
110–113
Identifiers
DOI: 10.1086/524074
PMID: 18171224
Source
Medline
License
Unknown

Abstract

We evaluated 1336 hepatitis B surface antigen-positive subjects consecutively observed in 79 Italian hospitals over a 6-month period. The proportion of hepatitis B e antigen-negative cases was 86.4%, that of patients coinfected with hepatitis D virus was 9.7%, and the rate of patients coinfected with hepatitis C virus was 16.8%. Multiple logistic regression analysis showed that age >49 years, alcohol abuse, and anti-hepatitis D virus and anti-hepatitis C virus positivity were independent predictors of progression to liver cirrhosis.

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