Affordable Access

deepdyve-link
Publisher Website

Chronic Exposure to Tramadol Induces Neurodegeneration in the Cerebellum of Adult Male Rats.

Authors
  • Ezi, Samira1, 2
  • Boroujeni, Mahdi Eskandarian3
  • Khatmi, Aysan2
  • Vakili, Kimia4
  • Fathi, Mobina4
  • Abdollahifar, Mohammad-Amin2
  • Aghajanpour, Fakhroddin2
  • Soltani, Reza2
  • Mirbehbahani, Seyed Hamidreza2
  • Khodagholi, Fariba5
  • Aliaghaei, Abbas6, 7
  • Farahani, Reza Mastery8
  • 1 Hearing Disorders Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Iran University of Medical Sciences, Tehran, Iran. , (Iran)
  • 2 Department of Cell Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , (Iran)
  • 3 Department of Human Molecular Genetics, Institute of Molecular Biology and Biotechnology, Faculty of Biology, Adam Mickiewicz University, Poznan, Poland. , (Poland)
  • 4 Student Research Committee, Faculty of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , (Iran)
  • 5 Neuroscience Research Center, Shahid Beheshti University of Medical Sciences, Tehran, Iran. , (Iran)
  • 6 Hearing Disorders Research Center, Loghman Hakim Hospital, Shahid Beheshti University of Medical Sciences, Iran University of Medical Sciences, Tehran, Iran. [email protected] , (Iran)
  • 7 Department of Cell Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. [email protected] , (Iran)
  • 8 Department of Cell Biology and Anatomical Sciences, School of Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran. [email protected] , (Iran)
Type
Published Article
Journal
Neurotoxicity Research
Publisher
Springer-Verlag
Publication Date
Apr 05, 2021
Identifiers
DOI: 10.1007/s12640-021-00354-w
PMID: 33818692
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

Tramadol is a centrally acting synthetic opioid analgesic and SNRI (serotonin/norepinephrine reuptake-inhibitor) that structurally resembles codeine and morphine. Given the tramadol neurotoxic effect and the body of studies on the effect of tramadol on the cerebellum, this study aims to provide deeper insights into molecular and histological alterations in the cerebellar cortex related to tramadol administration. In this study, twenty-four adult male albino rats were randomly and equally divided into two groups: control and tramadol groups. The tramadol group received 50 mg/kg of tramadol daily for 3 weeks via oral gavage. The functional and structural change of the cerebellum under chronic exposure of tramadol were measured. Our data revealed that treating rats with tramadol not only lead to cerebellum atrophy but also resulted in the actuation of microgliosis, neuroinflammatoin, and apoptotic biomarkers. Our results illustrated a significant drop in VEGF (vascular endothelial growth factor) level in the tramadol group. Additionally, tramadol impaired motor coordination and neuromuscular activity. We also identified several signaling cascades chiefly related to neurodegenerative disease and energy metabolism that considerably deregulated in the cerebellum of tramadol-treated rats. Overall, the outcomes of this study suggest that tramadol administration has a neurodegeneration effect on the cerebellar cortex via several pathways consisting of microgliosis, apoptosis, necroptosis, and neuroinflammatoin.

Report this publication

Statistics

Seen <100 times