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[Chronic benign neutropenia of childhood].

Authors
  • Azevedo, Ana Paula
  • Gamelas, Cristina
  • Teixeira, Valdemar
  • Contreiras, Marta
  • Monteiro, Rita
  • Vale, Maria Gorete
  • Durães, Fernando
Type
Published Article
Journal
Acta médica portuguesa
Publication Date
Jan 01, 2010
Volume
23
Issue
3
Pages
521–526
Identifiers
PMID: 20654274
Source
Medline
License
Unknown

Abstract

The term neutropenia concerns the reduction of the amount of circulating neutrophils in peripheric blood. The Chronic Benign Neutropenia of Childhood (CBNC) is characterized by the presence of a circulating neutrophils total number (absolute count) below 1,5 x 10(9)L, for over a six-month period. The diagnosis is established when the laboratorial changes occur during the first two years of life, without previous history of serious infections, nor neutrophils morphological changes, nor hypocellular bone marrow examination. The cellularity is normal or increased and a neutrophil maturation arrest at some phase can be observed. Generally, the whole process is solved by the age of four. Because this is a very rare clinical situation, it justifies a bibliographic revision about the theme. We present the clinical case of a 15 month-old-child, admitted with fever and diarrhea associated with neutropenia. Bone marrow aspiration, other laboratorial exams carried out during hospital internment and presented clinical evolution were consistent with CBNC diagnosis.

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