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Chromosome rearrangement by ectopic recombination in Drosophila melanogaster: genome structure and evolution.

Authors
  • Montgomery, E A
  • Huang, S M
  • Langley, C H
  • Judd, B H
Type
Published Article
Journal
Genetics
Publication Date
Dec 01, 1991
Volume
129
Issue
4
Pages
1085–1098
Identifiers
PMID: 1783293
Source
Medline
License
Unknown

Abstract

Ectopic recombination between interspersed repeat sequences generates chromosomal rearrangements that have a major impact on genome structure. A survey of ectopic recombination in the region flanking the white locus of Drosophila melanogaster identified 25 transposon-mediated rearrangements from four parallel experiments. Eighteen of the 25 were generated from females carrying X chromosomes heterozygous for interspersed repeat sequences. The cytogenetic and molecular analyses of the rearrangements and the parental chromosomes show: (1) interchromosomal and intrachromosomal recombinants are generated in about equal numbers; (2) ectopic recombination appears to be a meiotic process that is stimulated by the interchromosomal effect to about the same degree as regular crossing over; (3) copies of the retrotransposon roo were involved in all of the interchromosomal exchanges; some copies were involved much more frequently than others in the target region; (4) homozygosis for interspersed repeat sequences and other sequence variations significantly reduced ectopic recombination.

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