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[Chromosome alterations in tobacco smoke-associated tumors].

Authors
  • Szyfter, Krzysztof
  • Jarmuz, Małgorzata
  • Giefing, Maciej
  • Kiwarska, Katarzyna
Type
Published Article
Journal
Przegla̧d lekarski
Publication Date
Jan 01, 2007
Volume
64
Issue
10
Pages
865–870
Identifiers
PMID: 18409328
Source
Medline
License
Unknown

Abstract

A role of tobacco products in cancer incidence is commonly known and accepted. It is estimated that roughly 1/3 of all the cancers is resulted from previous exposure to tobacco. An impact of tobacco smoke carcinogens in formation of DNA lesions and mutations is well established. Contrary to that, less is known about rearrangements of chromosomes. Nevertheless, there are many indications associating rearrangements of chromosome arms 3p, 3q, 8q, 9p, 17p i 18q with a clastogenic activity of tobacco smoke. An evolution of cytogenetics from conventional techniques to molecular cytogenetics provides an opportunity to find some links between chromosome aberrations and activation of oncogenes as well as deactivation of tumor suppressor genes.

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