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Chromosome abnormalities in peripheral blood lymphocytes from untreated Hodgkin's patients. A possible evidence for chromosome instability.

Authors
  • Barrios, L
  • Caballín, M R
  • Mirò, R
  • Fuster, C
  • Berrozpe, G
  • Subías, A
  • Batlle, X
  • Egozcue, J
Type
Published Article
Journal
Human genetics
Publication Date
Apr 01, 1988
Volume
78
Issue
4
Pages
320–324
Identifiers
PMID: 3360446
Source
Medline
License
Unknown

Abstract

We describe the presence of a high frequency of spontaneous chromosome aberrations in lymphocytes from six untreated patients with Hodgkin's disease. The characteristics of the chromosome abnormalities observed suggest the existence of a certain degree of chromosome instability in these cases, that could be a predisposing factor for the development of malignancies.

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