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Chromosome 17q21 gene variants are associated with asthma and exacerbations but not atopy in early childhood.

Authors
  • Bisgaard, Hans
  • Bønnelykke, Klaus
  • Sleiman, Patrick M A
  • Brasholt, Martin
  • Chawes, Bo
  • Kreiner-Møller, Eskil
  • Stage, Malene
  • Kim, Cecilia
  • Tavendale, Roger
  • Baty, Florent
  • Pipper, Christian Bressen
  • Palmer, Colin N A
  • Hakonarsson, Hakon
Type
Published Article
Journal
American Journal of Respiratory and Critical Care Medicine
Publisher
American Thoracic Society
Publication Date
Feb 01, 2009
Volume
179
Issue
3
Pages
179–185
Identifiers
DOI: 10.1164/rccm.200809-1436OC
PMID: 19029000
Source
Medline
License
Unknown

Abstract

Variation at the chromosome 17q12-q21 locus was associated with approximately twofold increased risk of recurrent wheeze, asthma, asthma exacerbations, and bronchial hyperresponsiveness from early infancy to school age but without conferring risk of eczema, rhinitis, or allergic sensitization. These longitudinal clinical data show this locus to be an important genetic determinant of nonatopic asthma in children.

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