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Chromosomal localization of FLT4, a novel receptor-type tyrosine kinase gene.

Authors
  • Galland, F
  • Karamysheva, A
  • Mattei, M G
  • Rosnet, O
  • Marchetto, S
  • Birnbaum, D
Type
Published Article
Journal
Genomics
Publication Date
Jun 01, 1992
Volume
13
Issue
2
Pages
475–478
Identifiers
PMID: 1319394
Source
Medline
License
Unknown

Abstract

A new human gene encoding a putative receptor-type tyrosine kinase (RTK) was isolated by screening a placenta cDNA library with a mouse Flt3 probe. The deduced amino acid sequence of the intracellular region of the molecule showed that it was strongly related to the FLT1 and KDR/FLK1 gene products and to a lesser degree to members of the class III RTKs: FMS/CSF1R, PDGFRA/B, KIT, and FLT3. The gene was named FLT4. Cosmid clones of the mouse Flt4 gene were isolated. The human gene was localized to bands q34-q35 of chromosome 5, i.e., slightly telomeric to the CSF1R/PDGRFB tandem of genes, and the mouse homolog to chromosome 11, region A5-B1.

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