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[Chromosomal instability, microsatellite instability and CpG island methylator phenotype: roles in small intestinal carcinogenesis].

Authors
  • Bläker, H
  • Warth, A
  • Kloor, M
  • Schirmacher, P
Type
Published Article
Journal
Der Pathologe
Publication Date
Nov 01, 2011
Volume
32 Suppl 2
Pages
181–184
Identifiers
DOI: 10.1007/s00292-011-1509-0
PMID: 21915661
Source
Medline
License
Unknown

Abstract

Chromosomal instable carcinomas of the small intestine are distinguished from microsatellite instable and microsatellite and chromosomal stable tumors by a high frequency of KRAS mutations and low frequencies of CIMP and BRAF mutations. In microsatellite instable and microsatellite and chromosomally stable cancers, CIMP and BRAF/KRAS mutations are similarly distributed indicating common mechanisms of tumor initiation or progression in the molecular pathogenesis.

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