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Chromogranin A and neurone-specific enolase variations during the first 3 months of abiraterone therapy predict outcomes in patients with metastatic castration-resistant prostate cancer.

Authors
  • Fan, Liancheng1
  • Wang, Yanqing1
  • Chi, Chenfei1
  • Pan, Jiahua1
  • Xun, Shangguan1
  • Xin, Zhixiang1
  • Hu, Jianian1
  • Zhou, Lixin1
  • Dong, Baijun1
  • Xue, Wei1
  • 1 Department of Urology, Renji Hospital, School of Medicine, Shanghai Jiao Tong University, Shanghai, China. , (China)
Type
Published Article
Journal
British Journal of Urology
Publisher
Wiley (Blackwell Publishing)
Publication Date
Aug 01, 2017
Volume
120
Issue
2
Pages
226–232
Identifiers
DOI: 10.1111/bju.13781
PMID: 28107595
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

To determine the prognostic utility of serum chromogranin A (CgA) and neurone-specific enolase (NSE) variations during the first 3 months of abiraterone acetate (AA) treatment in patients with metastatic castration-resistant prostate cancer (mCRPC). The serum levels of CgA, NSE were measured at baseline and after 3 months of AA treatment in 40 patients with mCRPC. Outcome measures were prostate-specific antigen progression-free survival (PSA-PFS), radiographic PFS (rPFS), and overall survival (OS). CgA levels were not correlated with NSE levels (P = 0.296). In multivariate analysis the combination of CgA and NSE (≥1 marker positive vs both markers negative) and the combination of CgA and NSE elevation during the first 3 months of AA treatment (≥1 marker positive vs both markers negative) remained significant predictors of OS, rPFS, and PSA-PFS. We found that CgA and NSE elevation during the first 3 months of AA treatment and elevated baseline CgA and NSE levels were independent prognostic factors for OS, rPFS and PSA-PFS in patients with mCRPC treated with AA. This suggests that serial CgA and NSE evaluation may help clinicians in distinguishing patients with mCRPC who would obtain the best survival benefit from AA treatment. © 2017 The Authors BJU International © 2017 BJU International Published by John Wiley & Sons Ltd.

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