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Chromatin remodeling and repair of DNA double-strand breaks

Authors
  • Wong, Lai-Yee
  • Recht, Judith
  • Laurent, Brehon C.
Type
Published Article
Journal
Journal of Molecular Histology
Publisher
Springer-Verlag
Publication Date
Aug 08, 2006
Volume
37
Issue
5-7
Pages
261–269
Identifiers
DOI: 10.1007/s10735-006-9047-4
Source
Springer Nature
Keywords
License
Yellow

Abstract

Eukaryotic cells have developed conserved mechanisms to efficiently sense and repair DNA damage that results from constant chromosomal lesions. DNA repair has to proceed in the context of chromatin, and both histone-modifiers and ATP-dependent chromatin remodelers have been implicated in this process. Here, we review the current understanding and new hypotheses on how different chromatin-modifying activities function in DNA repair in yeast and metazoan cells.

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