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Chromatin Architecture in the Fly: Living without CTCF/Cohesin Loop Extrusion?: Alternating Chromatin States Provide a Basis for Domain Architecture in Drosophila.

Authors
  • Matthews, Nicholas E1
  • White, Rob1
  • 1 Department of Physiology, Development and Neuroscience, University of Cambridge, Cambridge, CB2 3DY, UK.
Type
Published Article
Journal
BioEssays
Publisher
Wiley (John Wiley & Sons)
Publication Date
Sep 01, 2019
Volume
41
Issue
9
Identifiers
DOI: 10.1002/bies.201900048
PMID: 31264253
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The organization of the genome into topologically associated domains (TADs) appears to be a fundamental process occurring across a wide range of eukaryote organisms, and it likely plays an important role in providing an architectural foundation for gene regulation. Initial studies emphasized the remarkable parallels between TAD organization in organisms as diverse as Drosophila and mammals. However, whereas CCCTC-binding factor (CTCF)/cohesin loop extrusion is emerging as a key mechanism for the formation of mammalian topological domains, the genome organization in Drosophila appears to depend primarily on the partitioning of chromatin state domains. Recent work suggesting a fundamental conserved role of chromatin state in building domain architecture is discussed and insights into genome organization from recent studies in Drosophila are considered. © 2019 The Authors. BioEssays Published by Wiley Periodicals, Inc.

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