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Choosing a route of administration for quadrivalent meningococcal polysaccharide vaccine: intramuscular versus subcutaneous.

Authors
  • Ruben, F L
  • Froeschle, J E
  • Meschievitz, C
  • Chen, K
  • George, J
  • Reeves-Hoché, M K
  • Pietrobon, P
  • Bybel, M
  • Livingood, W C
  • Woodhouse, L
Type
Published Article
Journal
Clinical infectious diseases : an official publication of the Infectious Diseases Society of America
Publication Date
Jan 01, 2001
Volume
32
Issue
1
Pages
170–172
Identifiers
PMID: 11118395
Source
Medline
License
Unknown

Abstract

A clinical trial was conducted to compare intramuscular (im) with subcutaneous (sc) routes for administration of quadrivalent meningococcal polysaccharide vaccine in 141 adults. Safety assessment showed the im route had reduced erythema (P<.01) and reduced headache on days 1 and 2 (P<.05). Serological testing for serum bactericidal antibody titers against capsular groups A and C did not detect significant differences.

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