(1) Some macrolides carry a strong risk of potentially severe drug interactions. (2) Erythromycin is the macrolide with the biggest risk of interactions. (3) Spiramycin is the macrolide with the smallest risk of interactions. Azithromycin and dirithromycin also seem to have a low risk of interactions, but they are far more recent and therefore less well known. (4) In first-line use, unless there are specific indications, a macrolide with a low risk of interactions should be used.
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This record was last updated on 07/02/2016 and may not reflect the most current and accurate biomedical/scientific data available from NLM.
The corresponding record at NLM can be accessed at https://www.ncbi.nlm.nih.gov/pubmed/11503822