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[Cholinesterase inhibitors in dementia: the precarious balance between efficacy and safety].

Authors
Type
Published Article
Journal
Nederlands tijdschrift voor geneeskunde
Publication Date
Volume
150
Issue
10
Pages
530–532
Identifiers
PMID: 16566413
Source
Medline
License
Unknown

Abstract

Cholinesterase inhibitors are widely prescribed in patients with Alzheimer's disease. Recently it has become clear that using these medications increases the risk of serious adverse events like cardiac arrhythmias, and some studies report a much-increased mortality in the treatment group on comparison with the placebo group. In the light of the at best, modest, treatment effects, we advocate that the safety of cholinesterase inhibitors should be the subject of continuing, intense scrutiny. Efforts should be made to delineate the profile of a true 'cholinergic deficiency syndrome', in order to be able to prescribe these medications to a group of patients in whom the benefits outweigh the risks.

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