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Cholinesterase as an inflammatory marker of subclinical infection of dairy cows infected by Neospora caninum and risk factors for disease.

Authors
  • Appelt, Marciana Anita1
  • da Silva, Aleksandro Schafer2
  • Cazarotto, Chrystian Jassana3
  • Machado, Gustavo4
  • Rodrigues, Rafael Sachet5
  • Norbury, Luke James6
  • Baldissera, Matheus D7
  • Alba, Davi F3
  • Gris, Anderson8
  • Mendes, Ricardo Evandro9
  • 1 Postgraduate course in Animal Production and Health, Instituto Federal Catarinense (IFC), Concórdia, SC, Brazil. , (Brazil)
  • 2 Graduate Program in Animal Science, Universidade do Estado de Santa Catarina (UDESC), Chapecó, SC, Brazil. Electronic address: [email protected] , (Brazil)
  • 3 Graduate Program in Animal Science, Universidade do Estado de Santa Catarina (UDESC), Chapecó, SC, Brazil. , (Brazil)
  • 4 College of Veterinary Medicine, North Carolina State University - NCSU, Raleigh, EUA, United States. , (United States)
  • 5 Veterinary Hospital, Universidade do Contestado (UNC), Canoinhas, SC, Brazil. , (Brazil)
  • 6 School of Science, Royal Melbourne Institute of Technology (RMIT) University, Bundoora, 3083, Victoria, Australia. , (Australia)
  • 7 Department of Physiology and Pharmacology, Universidade Federal de Santa Maria (UFSM), Santa Maria, RS, Brazil. , (Brazil)
  • 8 Veterinary Pathology Laboratory, IFC, Concórdia, SC, Brazil. , (Brazil)
  • 9 Postgraduate course in Animal Production and Health, Instituto Federal Catarinense (IFC), Concórdia, SC, Brazil; Veterinary Pathology Laboratory, IFC, Concórdia, SC, Brazil. Electronic address: [email protected] , (Brazil)
Type
Published Article
Journal
Comparative immunology, microbiology and infectious diseases
Publication Date
Oct 01, 2019
Volume
66
Pages
101330–101330
Identifiers
DOI: 10.1016/j.cimid.2019.101330
PMID: 31437690
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

The aim of this study was to evaluate the seroprevalence of Neospora caninum in dairy cows, as well as to verify the risk factors for N. caninum infection and inflammatory response in dairy cows. Using the indirect immunofluorescence reaction, the seroprevalence of neosporosis was determined to be 32.82%. Based on regression analysis, the presence of dogs at a farm increased the probability of a cow testing positive for N. caninum (OR = 20.01 [5.21-123.12]). These data suggest that N. caninum has a relevant prevalence in dairy cows of the Microregion of Rio do Sul (Brazil), with elevated frequencies of anti-N. caninum IgG. The data also suggest that the parasite is widely distributed in dairy herds of the micro-region, because 94.4% of properties screened had at least one seropositive animal. The principal risk factors for disease maintenance in herds may be considered the presence of dogs and absence of a diagnostic test when introducing new animals. Blood from these cows was used to measure variables related to the inflammatory response. Serum cholinesterase activity, as well as serum levels of globulins and C-reactive protein were higher in seropositive to N. caninum than in seronegative cows. Furthermore, the infection by parasite causes an intense inflammatory process, contributing to disease pathophysiology. Copyright © 2019 Elsevier Ltd. All rights reserved.

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