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Cholinergic modulation of separation distress in the domestic chick.

Authors
  • Sahley, T L
  • Panksepp, J
  • Zolovick, A J
Type
Published Article
Journal
European Journal of Pharmacology
Publisher
Elsevier
Publication Date
Jun 19, 1981
Volume
72
Issue
2-3
Pages
261–264
Identifiers
PMID: 7250210
Source
Medline
License
Unknown

Abstract

The effects of nicotine, carbachol, hexamethonium and scopolamine were investigated on distress vocalizations (DBs) of acutely isolated domestic chicks. Nicotine attenuated, while the antimuscarinic scopolamine increased the frequency of separation-induced DVs. Furthermore, the stress attenuating effects of nicotine were blocked by pretreatment with scopolamine. These results implicate muscarinic receptor participation in the control of separation-induced distress, and support the suggestion that nicotine-induced DV suppression may result from activation of behaviorally relevant muscarinic receptors via central release of acetylcholine.

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