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Cholinergic modulation of growth hormone secretion induced by galanin in rats.

Authors
  • Tanoh, T1
  • Shimatsu, A
  • Murakami, Y
  • Ishikawa, Y
  • Yanaihara, N
  • Imura, H
  • 1 Department of Internal Medicine, Kyoto University Faculty of Medicine, Japan. , (Japan)
Type
Published Article
Journal
Neuroendocrinology
Publication Date
Jul 01, 1991
Volume
54
Issue
1
Pages
83–88
Identifiers
PMID: 1717869
Source
Medline
License
Unknown

Abstract

The effects of cholinergic modulation by hexamethonium (HEX), tetraethylammonium (TEA), pirenzepine (PIR) and neostigmine on growth hormone (GH) secretion induced by galanin (GAL) were investigated in awake, freely moving male rats. Intracerebroventricular (i.c.v.) injection of GAL (0.6 nmol) caused a marked increase in plasma GH levels. Pretreatment with HEX (3 or 15 mg/kg BW), TEA (15 mg/kg BW) or PIR (0.5 mg/kg BW) significantly reduced the GAL-induced GH secretion. Pretreatment of animals with neostigmine (0.05 mg/kg BW) or with a specific antisomatostatin antiserum (10 microliters of 1:10 diluted with saline, i.c.v.) reversed the inhibition of GAL-induced GH secretion by HEX. These findings suggest that both nicotinic and muscarinic cholinergic mechanisms interact with the galanin-induced GH secretion by modulating hypothalamic somatostatin release.

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