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Cholinergic modulation of event-related oscillations (ERO).

Authors
  • Sanchez-Alavez, Manuel1
  • Robledo, Patricia2
  • Wills, Derek N1
  • Havstad, James2
  • Ehlers, Cindy L3
  • 1 Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-1501, La Jolla, CA 92037, USA.
  • 2 Laboratory of Neuropharmacology, Faculty of Health and Life Sciences, Universitat Pompeu Fabra, Plaça de la Mercè, 10-12, 08002 Barcelona, Spain. , (Spain)
  • 3 Department of Molecular and Cellular Neuroscience, The Scripps Research Institute, 10550 North Torrey Pines Road, SP30-1501, La Jolla, CA 92037, USA. Electronic address: [email protected]
Type
Published Article
Journal
Brain research
Publication Date
Apr 22, 2014
Volume
1559
Pages
11–25
Identifiers
DOI: 10.1016/j.brainres.2014.02.043
PMID: 24594019
Source
Medline
Keywords
License
Unknown

Abstract

The cholinergic system in the brain modulates patterns of activity involved in general arousal, attention processing, memory and consciousness. In the present study we determined the effects of selective cholinergic lesions of the medial septum area (MS) or nucleus basalis magnocellularis (NBM) on amplitude and phase characteristics of event related oscillations (EROs). A time-frequency based representation was used to determine ERO energy, phase synchronization across trials, recorded within a structure (phase lock index, PLI), and phase synchronization across trials, recorded between brain structures (phase difference lock index, PDLI), in the frontal cortex (Fctx), dorsal hippocampus (DHPC) and central amygdala (Amyg). Lesions in MS produced: (1) decreases in ERO energy in delta, theta, alpha, beta and gamma frequencies in Amyg, (2) reductions in gamma ERO energy and PLI in Fctx, (3) decreases in PDLI between the Fctx-Amyg in the theta, alpha, beta and gamma frequencies, and (4) decreases in PDLI between the DHPC-Amyg and Fctx-DHPC in the theta frequency bands. Lesions in NBM resulted in: (1) increased ERO energy in delta and theta frequency bands in Fctx, (2) reduced gamma ERO energy in Fctx and Amyg, (3) reductions in PLI in the theta, beta and gamma frequency ranges in Fctx, (4) reductions in gamma PLI in DHPC and (5) reduced beta PLI in Amyg. These studies suggest that the MS cholinergic system can alter phase synchronization between brain areas whereas the NBM cholinergic system modifies phase synchronization/phase resetting within a brain area.

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