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Choline acetyltransferase activity in discrete regions of the cat brain.

Authors
  • Nieoullon, A
  • Dusticier, N
Type
Published Article
Journal
Brain Research
Publisher
Elsevier
Publication Date
Aug 25, 1980
Volume
196
Issue
1
Pages
139–149
Identifiers
PMID: 7397518
Source
Medline
License
Unknown

Abstract

Choline acetyltransferase (CAT) activity was measured in the cat brain using a microdissection of the structures from frozen slices and an extremely sensitive radioisotopic assay for the enzyme. About 20 cerebral regions were chosen for study because of their role in sensorimotor integration. Highest CAT activity was found in the basal ganglia, followed by the thalamus and the cerebral cortex. The cerebellum had the lowest level of CAT. Special detailed studies were made in the substantia nigra, nucleus ventralis lateralis of the thalamus, areas 4 and 6 of the cerebral cortex, the red nucleus in the mesencephalon and the deep cerebellar nuclei in order to define the intranuclear distribution of their cholinergic innervation.

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