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Cholesteroloma of the breast: A 10 year retrospective review of 79 cases with radiology correlation.

Authors
  • Nam, Gahie1
  • Singer, Tisha M2
  • Lourenco, Ana P2
  • Wang, Yihong1
  • 1 Department of Pathology and Laboratory Medicine, Rhode Island Hospital and Lifespan Medical Center, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
  • 2 Department of Diagnostic Imaging, Rhode Island Hospital and Lifespan Medical Center, Warren Alpert Medical School of Brown University, Providence, Rhode Island, USA.
Type
Published Article
Journal
The Breast Journal
Publisher
Wiley (Blackwell Publishing)
Publication Date
Nov 01, 2019
Volume
25
Issue
6
Pages
1177–1181
Identifiers
DOI: 10.1111/tbj.13441
PMID: 31280486
Source
Medline
Keywords
Language
English
License
Unknown

Abstract

A cholesteroloma or cholesterol granuloma of the breast is an uncommon lesion representing an inflammatory/reactive process with unclear etiology. In this study, we reviewed our 10-year experience with cholesteroloma of the breast with clinical, radiologic, and histopathological correlation. Seventy-nine cases were selected. The mean patient age was 57.7 (range 25-90) years old. Patients had hypercholesterolemia with mean blood cholesterol level of 201 mg/dL (P < 0.001). The mean body mass index (BMI) was 26.7 kg/m2 (P = 0.1976). The indications for the breast biopsies were mass lesion on radiology (85.5%, n = 65) and microcalcifications (10.5%, n = 8). Of the 65 cases of the mass lesions, 52 presented as solid masses and 13 were cystic. On the diagnostic mammogram or ultrasound, 81.9% were BI-RADS 4% and 6.9% were BI-RADS 5. Macrocysts were the most common pathological finding associated with cholesteroloma suggesting the etiology of cholesteroloma may be the result of repair process from obstruction and rupture of the macrocysts. Six cases (9.2%) of cholesterolomas had persistent masses during follow-up. The recognition of this lesion and radio-pathological correlation can help us better understand this entity and distinguish it from its mimickers. © 2019 Wiley Periodicals, Inc.

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