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Cholesterol esterification in mouse peritoneal macrophages in the presence of pathological human plasma lipoproteins.

Authors
  • Rotheneder, M
  • Kostner, G M
Type
Published Article
Journal
Biological chemistry Hoppe-Seyler
Publication Date
Dec 01, 1986
Volume
367
Issue
12
Pages
1219–1222
Identifiers
PMID: 3828071
Source
Medline
License
Unknown

Abstract

Mouse peritoneal macrophages were incubated with abnormal lipoproteins (LP-X, HDL-E, VLDL-p, IDl-p and LDL-p) from a patient with secondary deficiency in phosphatidylcholine-sterol acyltransferase, or with phosphatidylcholine/cholesterol liposomes, and the stimulation of cholesteryl ester formation was studied. Acetylated low density lipoproteins served as a control. It was found that macrophages incubated with LP-X, the other pathological lipoproteins or with liposomes did not show an enhanced cholesterol esterification. Also HDL-E had no effect despite of its high apoE content and the fact that apoE has been postulated to be the agonist in beta-VLDL binding to macrophages.

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