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Cholesterol efflux potential and antiinflammatory properties of high-density lipoprotein after treatment with niacin or anacetrapib.

Authors
  • Yvan-Charvet, Laurent
  • Kling, Jelena
  • Pagler, Tamara
  • Li, Hongna
  • Hubbard, Brian
  • Fisher, Tim
  • Sparrow, Carl P
  • Taggart, Andrew K
  • Tall, Alan R
Type
Published Article
Journal
Arteriosclerosis Thrombosis and Vascular Biology
Publisher
Ovid Technologies Wolters Kluwer -American Heart Association
Publication Date
Jul 01, 2010
Volume
30
Issue
7
Pages
1430–1438
Identifiers
DOI: 10.1161/ATVBAHA.110.207142
PMID: 20448206
Source
Medline
License
Unknown

Abstract

Niacin treatment caused a moderate increase in the ability of HDL to promote net cholesterol efflux, whereas inhibition of cholesteryl ester transfer protein via anacetrapib led to a more dramatic increase in association with enhanced particle functionality at higher HDL concentrations. All HDLs exhibited potent ability to suppress macrophage toll-like receptor 4-mediated inflammatory responses, in a process partly dependent on cholesterol efflux via ABCA1 and ABCG1.

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