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Cholestasis enhances liver ischemia/reperfusion-induced coagulation activation in rats.

Authors
  • Kloek, Jaap J
  • Levi, Marcel
  • Heger, Michal
  • van der Loos, Chris M
  • Gouma, Dirk J
  • van Gulik, Thomas M
Type
Published Article
Journal
Hepatology research : the official journal of the Japan Society of Hepatology
Publication Date
Feb 01, 2010
Volume
40
Issue
2
Pages
204–215
Identifiers
DOI: 10.1111/j.1872-034X.2009.00579.x
PMID: 19737317
Source
Medline
License
Unknown

Abstract

Cholestasis significantly enhances I/R-induced hepatic damage and inflammation that concurs with an increased activation of coagulation and fibrinolysis.

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