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Cholera transmission: the host, pathogen and bacteriophage dynamic.

Authors
  • Nelson, Eric J
  • Harris, Jason B
  • Morris, J Glenn Jr
  • Calderwood, Stephen B
  • Camilli, Andrew
Type
Published Article
Journal
Nature Reviews Microbiology
Publisher
Springer Nature
Publication Date
Oct 01, 2009
Volume
7
Issue
10
Pages
693–702
Identifiers
DOI: 10.1038/nrmicro2204
PMID: 19756008
Source
Medline
License
Unknown

Abstract

Zimbabwe offers the most recent example of the tragedy that befalls a country and its people when cholera strikes. The 2008-2009 outbreak rapidly spread across every province and brought rates of mortality similar to those witnessed as a consequence of cholera infections a hundred years ago. In this Review we highlight the advances that will help to unravel how interactions between the host, the bacterial pathogen and the lytic bacteriophage might propel and quench cholera outbreaks in endemic settings and in emergent epidemic regions such as Zimbabwe.

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