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Cholecalciferol or 25-hydroxycholecalciferol neither prevents nor treats adenomas in a rat model of familial colon cancer.

Authors
  • Irving, Amy A
  • Plum, Lori A
  • Blaser, William J
  • Ford, Madeline R
  • Weng, Chao
  • Clipson, Linda
  • DeLuca, Hector F
  • Dove, William F
Type
Published Article
Journal
Journal of Nutrition
Publisher
Oxford University Press
Publication Date
Feb 01, 2015
Volume
145
Issue
2
Pages
291–298
Identifiers
DOI: 10.3945/jn.114.204396
PMID: 25644350
Source
Medline
Keywords
License
Unknown

Abstract

No evidence for protection against colon tumor development was seen with lower dose supplementation with either cholecalciferol or 25-hydroxycholecalciferol. Thus, the association between sunlight exposure and the incidence of colon cancer may involve factors other than vitamin D concentrations. Alternative hypotheses warrant investigation. Furthermore, this study provides preliminary evidence for the need for caution regarding vitamin D supplementation of humans at higher doses, especially in individuals with sufficient serum 25(OH)D3 concentrations.

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