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Chloride-sensitive renal microangiopathy in the stroke-prone spontaneously hypertensive rat.

Authors
  • Tanaka, M
  • Schmidlin, O
  • Olson, J L
  • Yi, S L
  • Morris, R C
Type
Published Article
Journal
Kidney international
Publication Date
Mar 01, 2001
Volume
59
Issue
3
Pages
1066–1076
Identifiers
PMID: 11231362
Source
Medline
License
Unknown

Abstract

In the SHRSP, (1) like cerebral microangiopathy, renal microangiopathy is selectively Cl(-) sensitive and hence, systemic microangiopathy is as well; (2) Cl(-) likely amplifies microangiopathy by exacerbating hypertension and possibly also by increasing PRA; and (3) Cl(-) might increase blood pressure and PRA by further constricting the renal afferent arteriole.

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