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Chlamydophila pneumoniae and the etiology of late-onset Alzheimer's disease.

Authors
  • Balin, Brian J
  • Little, C Scott
  • Hammond, Christine J
  • Appelt, Denah M
  • Whittum-Hudson, Judith A
  • Gérard, Hervé C
  • Hudson, Alan P
Type
Published Article
Journal
Journal of Alzheimer s Disease
Publisher
IOS Press
Publication Date
April 2008
Volume
13
Issue
4
Pages
371–380
Identifiers
PMID: 18487846
Source
Medline
License
Unknown

Abstract

Sporadic, late-onset Alzheimer's disease (LOAD) is a non-familial, progressive neurodegenerative disease that is now the most common and severe form of dementia in the elderly. That dementia is a direct result of neuronal damage and loss associated with accumulations of abnormal protein deposits in the brain. Great strides have been made in the past 20 years with regard to understanding the pathological entities that arise in the AD brain, both for familial AD ( approximately 5% of all cases) and LOAD ( approximately 95% of all cases). The neuropathology observed includes: neuritic senile plaques (NSPs), neurofibrillary tangles (NFTs), neuropil threads (NPs), and often deposits of cerebrovascular amyloid. Genetic, biochemical, and immunological analyses have provided a relatively detailed knowledge of these entities, but our understanding of the "trigger" events leading to the many cascades resulting in this pathology and neurodegeneration is still quite limited. For this reason, the etiology of AD, in particular LOAD, has remained elusive. However, a number of recent and ongoing studies have implicated infection in the etiology and pathogenesis of LOAD. This review focuses specifically on infection with Chlamydophila (Chlamydia) pneumoniae in LOAD and how this infection may function as a "trigger or initiator" in the pathogenesis of this disease.

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