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Chiral 2,2-disubstituted cyclopropanecarboxylic acids: Effective derivatizing agents for analysis of enantiomeric purity of alcohols and for resolution of 1,1'-bi-2-naphthol

Authors
  • Kim, HC
  • Choi, S
  • Kim, H
  • Ahn, KH
  • Koh, JH
  • Park, J
Publication Date
Jun 02, 1997
Source
OASIS@POSTECH
Keywords
License
Unknown
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Abstract

The enantiomeric purities of secondary alcohols can be easily analyzed by GC and HPLC through derivatization to the esters of 2,2-disubstituted cyclopropanecarboxylic acids 1, and by H-1 NMR analysis of the esters of 2,2-diphenylcyclopropanecarboxylic acid (Ib). In addition racemic 1,1'-bi-2-naphthol is easily resolved through derivatization to monoesters of 2,2-dimethy]cyclopropanecarboxylic acid (1a), which are crystallized selectively and sequentially in high yields with high optical purities. (C) 1997 Elsevier Science Ltd. / X / 1 / 1 / 17 / scie / scopus

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